L A F U G A
Laboratory for Functional Genome Analysis
Model Organisms
Animal models are essential to understand the genetics and pathogenesis of human diseases. Mouse models are established in a genotype- and a phenotype-driven way. A broad spectrum of transgenic (incl. pronuclear microinjection of BACs), knock-out and knock-in techniques is established in the LAFUGA animal models platform. In addition we have recovered a large number of mouse mutants with clinically relevant phenotypes within the Munich ENU Mouse Mutagenesis Screen.
Besides the generation of mouse models, LAFUGA provides gene transfer techniques for the generation of livestock models for various applications, including xenotransplantation, diabetes and prion research. The technology basis includes nuclear transfer using genetically modified donor cells as well as high performance multitransgenics by using lentiviral vectors.
