Research
Main objectives
Comparative analysis of gene expression changes in the endometrium during early pregnancy and the sexual cycle in cattle, pig and horse
Across-species analysis of mRNA expression data
Investigation of the role of regulatory RNAs, e.g. micro RNAs (miRNAs)
Analysis in three important domestic animals
Similarities:
Delayed implantation
Non-invasive implantation (epitheliochorial)
Differences:
Different pregnancy recognition signals
Different conceptus development
Different types of placentation
Research tools
Affymetrix GeneChip® technology
Bovine Gene 1.0 ST Array
Porcine Gene 1.0 ST Array
Agilent OpenArray platform
Genome-wide arrays (latest design)
miRNA arrays
Illumina RNAseq
Millions of short reads per sample
High sensitivity (<1 mRNA/cell)
De novo transcriptome sequencing
Projects/Funding
Comparative Endometrium Biology (COMPENDIUM) BMBF FUGATOplus Effects of Diabetes Type 1 on endometrial gene expression in the rabbit during the preimplantation phase Deutsche Diabetes Gesellschaft Mechanisms of embryo-maternal communication – transcriptome changes in bovine endometrium during early pregnancy DFG FOR 478** Dynamic gene expression changes in equine endometrium during the sexual cycle ReproZentrum
LMU Munich* expired 30.06.2010
** expired 31.12.2009
